We engineer biology
with uncommon taste
Helix & Tide is a small team crafting programmable therapies and tools. We start with messy biological reality and design toward precise, human outcomes.
What we do
We design therapeutic modalities and enabling tools across gene editing, RNA delivery, and engineered microbes. Our style is to work close to the data and the cell—tight feedback loops between wet lab, computation, and product.
- Programs anchored by clear biomarkers and assayable endpoints.
- Compact, automation-friendly protocols; everything versioned.
- Open to collaborations where our taste and platform are unfair advantages.
Pipeline
Gene Editing
Compact editors for ex vivo and in vivo use. Emphasis on high on-target efficiency and practical delivery constraints.
CRISPR • base editing • prime
RNA Delivery
Formulations tuned by data-driven structure–function models. Tissue-selective delivery without baroque chemistry.
LNPs • peptides • targeting
Engineered Microbes
Chassis design for durable, contained function in complex environments. Safety-first genetic circuits.
gut • skin • soil
Technology
Wet lab × ML
We close the loop between high-throughput assays and compact models. Most of our improvements come from careful datasets and simpler models, not just bigger ones.
Automation & provenance
Protocols are written to be replayable by people or robots. Every figure is traceable back to raw data and reagent lots.
Safety posture
Design-time safeguards, negative controls, and conservative release criteria. If in doubt, we slow down.
Quick Look
// Compact pseudo-code sketch
assay := design(readout="functional")
for variant in library:
measure := assay.run(variant)
model.fit(variant.features, measure)
if model.predict(next) improves:
iterate(bench, model)
Selected Publications
- Programmable RNA delivery at organ scale — Smith et al. (2024). Bioengineering Reports.
- Compact base editors for primary cells — Patel et al. (2023). Gene Therapy Letters.
- Contained microbial circuits — Nguyen & Rao (2022). Systems Biology.
Careers
We hire scientists and engineers who like doing careful work with taste. Generalists welcome. If this sounds like you, send us a note.
Email [email protected]Hiring Now
- Scientist, RNA Formulations
- Engineer, Lab Automation
- Computational Biologist